High-Quality Acylglycines Analytical Standards by Merck — Essential Reference Materials for Biomarker & Metabolite Analysis
Precise diagnosis of inborn errors of metabolism requires reliable reference materials. High-quality Acylglycines Analytical Standards from Merck enable accurate biomarker identification and support amino acid and fatty acid metabolism testing for clinical and research applications.
Why use acylglycines reference materials
- Supports precise diagnosis of inborn errors of metabolism: Provides reliable reference materials for testing workflows used in the biochemical diagnosis of selected inborn errors of metabolism.
- Enables accurate biomarker identification: Helps laboratories identify abnormal acylglycine concentrations used as biomarkers in the detection of selected fatty acid oxidation disorders and organic acidemias.
- Strengthens newborn screening method development: Suitable for qualitative use and method development in newborn screening and detection of metabolic diseases.
- Improves access to diagnostically relevant urinary targets: Supports analysis of urinary metabolites present in amounts below the detection limit in routine analysis of organic acids.
- Extends utility across selected metabolic disease investigations: Helps address testing needs for conditions including medium chain acyl-CoA dehydrogenase deficiency, isovaleric acidemia, and β-ketothiolase deficiency.
What these acylglycines reference materials are
- Portfolio Composition: A comprehensive range of analytical standards consisting of native acylglycines.
- Clinical Relevance: Clinically relevant acylglycines are included in the portfolio.
- Acylglycine Classes: Saturated, unsaturated, dicarboxy-, and aromatic acylglycines are part of the portfolio.
Application and usage
- Qualitative use: Suitable for qualitative use in acylglycine analysis.
- Newborn screening method development: Used for method development in newborn screening.
- Metabolic disease detection by mass spectrometry: Used in mass spectrometry-based detection of metabolic diseases, including MS/MS, GC/MS, and LC/MS workflows.
- Combined metabolic testing context: Testing of acylglycines is often performed alongside plasma acylcarnitines and urine organic acids.
- Urine acylglycines analysis: Particularly effective for the biochemical diagnosis and detection of selected inborn errors of metabolism, such as fatty acid oxidation disorders and organic acidemias.
- Target urinary metabolite measurement: Measures target urinary metabolites present in amounts below the detection limit in routine analysis of organic acids, including in medium chain acyl-CoA dehydrogenase deficiency, isovaleric acidemia, and β-ketothiolase deficiency.
Acylglycines analytical standards product list
| Product name | ID | Pack Size |
|---|---|---|
| N-Acetylglycine | C2 | 10 mg/50 mg |
| N-Butyrylglycine | C4 | 10 mg/50 mg/250 mg |
| N-Isobutyrylglycine | iC4 | 10 mg/50 mg/250 mg |
| N-Valerylglycine | C5 | 10 mg/50 mg/250 mg |
| N-Isovalerylglycine | iC5 | 10 mg/50 mg |
| N-Heptanoylglycine | C7 | 10 mg/50 mg/250 mg |
| N-Octanoylglycine | C8 | 10 mg/50 mg/250 mg |
| N-Decanoylglycine | C10 | 10 mg/50 mg/250 mg |
| N-Lauroylglycine | C12 | 10 mg/50 mg/250 mg |
| N-Myristoylglycine | C14 | 10 mg/50 mg/250 mg |
| N-Palmitoylglycine | C16 | available soon |
| N-Stearoylglycine | C18 | 10 mg/50 mg/250 mg |
| N-Valproylglycine | 10 mg/50 mg/250 mg | |
| N-(2-Methylbutyryl)glycine | 10 mg/50 mg/250 mg | |
| N-Pivaloylglycine | 10 mg/50 mg/250 mg | |
| N-Malonylglycine | C3DC | 10 mg/50 mg/250 mg |
| (±)-N-Methylmalonylglycin | 3-MeC3DC | 10 mg/50 mg/250 mg |
| N-Succinylglycine | C4DC | 10 mg/50 mg/250 mg |
| N-Glutarylglycine | C5DC | 10 mg/50 mg/250 mg |
| N-Adipoylglycine | C6DC | 10 mg/50 mg/250 mg |
| N-Suberylglycine | C8DC | 10 mg/50 mg/250 mg |
| N-Sebacoylglycine | C10DC | 10 mg/50 mg/250 mg |
| N-Tigloylglycine | C5:1 | 10 mg/50 mg |
| N-(3-Methylcrotonyl)glycine | 10 mg/50 mg | |
| N-(2-Phenylacetyl)glycine | C2Ar | 10 mg/50 mg/250 mg |
| N-(3-Phenylpropionyl)glycine | C3Ar | 10 mg/50 mg/250 mg |
| N-Cinnamoylglycine | C9Ar | 10 mg/50 mg/250 mg |
| N-[2-(4-Hydroxyphenyl)acetyl]glycine | 10 mg/50 mg/250 mg |
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