Cell Culture Optimized Poloxamer 188 – Merck Emprove® Expert Grades for Shear Protection in Bioprocessing

Maintaining cell viability and density is critical for successful biomanufacturing. Poloxamer 188 is the industry standard for protecting mammalian cells from shear stress in bioreactors. This page explains how Cell Culture Optimized Poloxamer 188 Emprove® Expert grades support consistent cell culture performance, predictable shear protection, and process intensification in bioprocessing.

Benefits of Cell Culture Optimized Poloxamer 188

• Shear protection: Helps protect mammalian cells from shear stress in bioreactors.
• Cell culture robustness: Supports mammalian cells exposed to shear from sparging.
• Predictable performance: Helps manage challenges associated with lot-to-lot variation in Poloxamer 188.
• Consistent quality: Provides reliable performance and consistency for commercial cell culture processes.
• Process intensification support: Supports manufacturing challenges associated with increasing cell densities and fed-batch or perfusion production.

Features of Cell Culture Optimized Poloxamer 188

• Surface-active nonionic polymer: Poloxamer 188 is a surface-active nonionic polymer used in cell culture media.
• Emprove® Expert format: Available as Poloxamer 188 Emprove® Expert grades.
• Grade options: Two Emprove® Expert grades are available to meet different compendial requirements.
• Compendial alignment: Each grade is designed to support different biopharmaceutical compendial needs.
• Analytical support framework: Proprietary analytical and biological tests were developed and validated to investigate lot-to-lot variability.

Technical Specifications for Cell Culture Optimized Poloxamer 188

Applications and Usage of Cell Culture Optimized Poloxamer 188

• Cell culture media: Used as a shear protectant in cell culture media.
• Bioreactor protection: Helps protect mammalian cells from shear stress in bioreactors.
• Sparging-related stress: Relevant in processes where sparging contributes to hydrodynamic stress.
• Large-scale processing: Suitable for large-scale cell culture operations.
• Process support: Applicable to manufacturing workflows with increasing cell densities, including fed-batch and perfusion.

Chemical Express, with over 23 years of expertise, is the official distributor of Merck in Thailand. Access Cell Culture Optimized Poloxamer 188 Emprove® Expert grades and other bioprocessing solutions directly through Chemical Express to support reliable manufacturing.