CellPrime® rAlbumin by Merck: Animal-Free Recombinant Albumin for Consistent, Safe Cell Culture and Bioprocessing

Achieve unparalleled consistency in your cell culture and bioprocessing with CellPrime® rAlbumin by Merck, an animal-free recombinant albumin solution designed for modern biomanufacturing. This non-animal origin, recombinant albumin supplement addresses the critical demand for batch-to-batch reliability and contaminant safety in vaccine manufacturing and cell therapy. Learn how CellPrime® rAlbumin supports robust media optimization while eliminating risks associated with blood-derived proteins.

Why Choose CellPrime® rAlbumin

• Media development flexibility: Ideally suited for media development, optimization, and supplementation in cell culture and bioprocessing workflows.
• Reduced process variability: Replaces human or bovine serum albumin to remove the variability introduced by blood-derived proteins.
• Contaminant safety: Safeguards against adventitious virus or prion contamination associated with human or bovine serum–derived albumin.
• Reliable consistency: Combines excellent quality with superior performance and lot-to-lot consistency for more dependable use across batches.
• Animal-free alternative: Provides a non-animal origin substitute for serum albumin in applications where animal-free supplementation is preferred.
• Operational risk mitigation: Helps reduce the risk of facility contamination that could trigger manufacturing shutdowns and downstream supply shortages for patients.
• Long shelf-life: Offers a shelf-life of 2 years at the recommended storage temperature.

What CellPrime® rAlbumin Is

• Product Classification: Recombinant human albumin (rAlbumin) supplement synthesized as a non-glycosylated protein.
• Expression System: Protein produced in Pichia pastoris utilizing a synthetic DNA insert for the human albumin gene sequence.
• Molecular Composition: Non-animal origin (NAO) formulation devoid of human or animal-derived components in cell banks, raw materials, or final processing.
• Chemical Formulation: Final product and manufacturing process excludes the use of octanoate (caprylic acid) stabilizers.
• Manufacturing Standard: Produced under GMP conditions in accordance with EXCiPACT™ certification requirements.
• Safety Framework: Structural alignment with the “Prevent, Detect, Remove” viral safety architecture.
• Regulatory Documentation: Product designation for inclusion within the Emprove® program for regulatory dossiers.

Technical Specifications

• CellPrime® rAlbumin is > = 98% pure.
• CellPrime® rAlbumin is provided as a 10% (w/v), 0.2 μm filtered solution in PBS (25 mM phosphate buffer, 145 mM NaCl, pH 7.2).
• Shelf-life: 2 years at recommended storage temperature.
• Storage and shipping: Store and ship CellPrime® rAlbumin refrigerated at 2 – 8 °C.
• Handling: Keep refrigerated or on ice while handling.
• Freezing: Do not freeze.

Applications and Use Cases

• Media development and optimization: Ideally suited for chemically defined media development and optimization in cell culture workflows.
• Animal-free substitute for serum albumin: Serves as an animal-free replacement for human or bovine serum albumin in cell culture and bioprocessing.
• Supplement mix for cell culture media formulations: CellPrime® rAlbumin can replace serum albumin of bovine or human serum origin in combination with recombinant transferrin and recombinant insulin as a supplement mix in cell culture media formulations.
• Expansion of key production cell lines: CellPrime® rAlbumin is the preferred supplement for the expansion of MDCK, Vero, MRC-5, and HEK 293 (T) cell lines used in virusborne vaccine manufacturing or cell and gene therapies.
• Expansion of immune and hematopoietic cell types: CellPrime® rAlbumin is the preferred supplement for the expansion of mononuclear and hematopoietic stem cells and T-lymphocytes used in virusborne vaccine manufacturing or cell and gene therapies.
• Expansion of stem cell populations: CellPrime® rAlbumin is the preferred supplement for the expansion of human mesenchymal stem cells (MSC), human embryonic stem cells (hESC), and induced pluripotent stem cells (iPSC) used in virusborne vaccine manufacturing or cell and gene therapies.

CellPrime® rAlbumin Product Options

Chemical Express, with over 23 years of expertise, is the official distributor of Merck in Thailand. You can purchase CellPrime® rAlbumin and other high-quality supplements through Chemical Express, ensuring trusted access to Merck’s complete range for your bioprocessing requirements.