Cyrene™ Solvent by Merck: BioRenewable Alternative for Analytical Chemistry and Chromatography

Laboratories and industrial chemists face growing demands for safer, environmentally responsible solvents that do not compromise performance. Cyrene™ rises to this challenge as an innovative dipolar aprotic solvent, offering a biorenewable alternative to REACH-restricted options like NMP and DMF. This page details Cyrene™’s standout features, replacements, and real-world applications.

Why Choose Cyrene™

• Greener solvent choice: Offers a biorenewable alternative to common REACH-restricted solvents such as NMP.
• Renewable sourcing: Produced from renewable resources.
• Safer end of life disposal: Safe for end of life disposal and decomposes into CO₂ and H₂O.
• Safer handling profile: Safer to handle, with no mutagenic or genotoxic concerns.
• High biodegradation: Shows 99% biodegradation in 28 days.
• Incineration stability: Stable during incineration.
• Broader process usability with blends: Cyrene™ γ-Valerolactone Blend and Cyrene™ 2-Methyltetrahydrofuran Blend offer considerably lower viscosity, which simplifies handling and broadens applicability.
• Improved automated process performance with blends: The Cyrene™ blends can lead to even higher product yields in automated processes while maintaining the excellent efficacy of Cyrene™.

Cyrene™ Features

• Cyrene™ solvent: A new dipolar aprotic alternative to common REACH-restricted solvents such as N-methyl-2-pyrrolidone (NMP).
• Alternative solvents referenced: An alternative for NMP, DMF, and sulfolane.
• End-of-life decomposition: Cyrene™ decomposes into CO₂ and H₂O.
• Product family element: Cyrene™ is also available as Cyrene™ γ-Valerolactone Blend and Cyrene™ 2-Methyltetrahydrofuran Blend.
• Blend composition: These blends combine classic Cyrene™ with two BioRenewable solvents.
• Blend property: The Cyrene™ γ-Valerolactone Blend and Cyrene™ 2-MeTHF Blend offer considerably lower viscosity.

Applications and Reactions

Applications:

• Exceeds NMP’s dispersive ability for graphene solutions by an order of magnitude.
• Used as an alternative to DMF in synthesis of metal-organic frameworks.
• Comparable replacement for DMF in amide and dipeptide coupling reactions.

Named reactions:

• Sonogashira.
• Cacchi-type annulation.
• Synthesis of metal-organic frameworks.
• Suzuki-Miyaura coupling reaction.
• Synthesis of ureas.

Chemical Express, with over 23 years of expertise, is the official distributor of Merck in Thailand. Discover Cyrene™ and related analytical products for your needs through Chemical Express’s extensive and trusted portfolio.