Sf-RVN® Platform by Merck: Enhanced Safety & Productivity for Protein Expression, VLPs, and Gene Therapy

Bioprocessing industries require safe, reliable cell culture solutions to meet strict quality standards and mitigate contaminants. The Sf-RVN® Platform, powered by Merck, addresses these challenges with a rhabdovirus-negative Spodoptera frugiperda (Sf9) cell line paired with EX-CELL® CD Insect Cell Medium, helping reduce virus-related risk while providing optimal performance for recombinant protein production, viral vaccines, and gene therapy applications.

Why Choose the Sf-RVN® Platform

• Improved safety profile: Enhances risk mitigation in bioprocesses with a rhabdovirus-free alternative.
• High performance: Optimized to achieve low doubling time, high cell viability, and excellent productivity.
• Production versatility: Supports production of recombinant proteins, virus-like particles (VLPs) for viral vaccines, and adeno-associated viruses (AAV) for genetic disease therapies.

Sf-RVN® Platform Components and Key Features

• Patented Sf9 rhabdovirus-negative insect cell line, adventitious agent tested and GMP banked in EX-CELL® CD Insect Cell Medium, with full traceability and documentation.
• EX-CELL® CD Insect Cell Medium is chemically defined, animal component free, and supports growth of multiple insect cell lines.
• Medium formulation is optimized for the Sf-RVN® Insect Cell Line and available in both liquid and dry powdered formats.
• The platform includes a technical user guide with detailed protocols and supporting regulatory and quality documentation.

Applications and Intended Use of the Sf-RVN® Platform

• Recombinant protein production: Supports recombinant protein production in insect cell systems.
• Viral vaccine production: Enables production of viral vaccines such as virus-like particles (VLPs).
• Gene therapy applications: Supports production of adeno-associated vectors and adeno-associated viruses (AAV) for gene therapy and genetic disease treatment.

With over 23 years of expertise, Chemical Express is Thailand’s official distributor of Merck. Access the full range of Merck products, including the Sf-RVN® Platform and related bioprocessing solutions, through Chemical Express for proven quality, technical support, and trusted regulatory documentation.