Synple Chem – Automated Chemical Synthesis Platform by Synple | Speed, Safety and Reproducibility for Advanced Chemistry

Streamline your laboratory workflow with the Synple Chem automated chemical synthesis platform.

Why Choose Synple Chem Automated Chemical Synthesis Platform

• Reduced hands-on time: Cuts user time to about 5 to 10 minutes, compared with manual synthesis that can take several hours.
• Higher laboratory efficiency: Increases speed and overall efficiency while freeing time to focus on other important experiments.
• Improved reproducibility: Delivers optimized reactions with better reproducibility for routine synthesis and optimization work.
• Lower risk of human error: Reduces operator error through automated processing and optimized reaction execution.
• Enhanced safety: Minimizes user exposure to chemicals through a fully enclosed reaction process that complies with the latest safety standards.
• Reduced contamination risk: Lowers cross-contamination risk through automated washing between runs.
• Cost savings: Offers a more economical alternative to manual chemical synthesis through lower personnel and reagent costs.
• Less chemical waste: Uses minimum reagents and solvents in an optimized reaction sequence, greatly reducing waste.
• Convenient operation: Requires no special training or detailed chemistry knowledge for routine use.
• Flexible experiment planning: Enables unattended overnight and multi-step synthesis planning for routine optimization.

Platform Features and System Components

• Platform architecture: Benchtop synthesizer combined with pre-filled reagent cartridges for automated organic chemical synthesis.
• Programmable handling scope: End-to-end programmable operation covering reaction setup, execution, workup, isolation, and purification.
• Reaction configuration: Fully enclosed reaction format with synthesis occurring in the cartridge itself or in the reaction vial.
• System format: Modular system configured for a range of reactions through cartridge-based operation.
• Fluidic components: Synple 2 incorporates two syringe pumps and two rotary valves.
• Integrated hardware: Synple 2 includes a sample holder, cartridge holder, RFID chip scanner, and touchscreen.
• Cartridge design: Each pre-filled cartridge contains the reagents required to generate, isolate, and purify the product.
• Method recognition: Cartridge RFID chip encoded with the reaction method for automated method loading after scanning.
• Experiment modes: Platform supports parallel or sequential experiments and routine optimization.
• Cleaning function: Automated wash sequence prepares the instrument for subsequent runs.

Technical Specifications

• Dimensions: W 26 cm, H 36 cm, D 49 cm
• Setup time: 5 minutes
• User time: 5 to 10 minutes
• Internal fluid handling components: Two syringe pumps and two rotary valves
• Reaction classes available: 8 (including N-heterocycle formation, reductive amination, protein degrader formation, biotin tagging, Mitsunobu reaction, Boc protection, Boc deprotection, and fluorination)
• Reagents across cartridge range: More than 40

Application and Basic Operation

• Primary use: Synple Chem automated chemical synthesis platform is used for fully automated organic chemical synthesis with pre-filled reagent cartridges that generate, isolate, and purify research products.
• Workflow scope: The platform handles the synthesis process end to end, including reaction setup, execution, workup, isolation, and purification through programmable operation.
• Reaction coverage: Synple cartridges are offered for a variety of reactions, including N-heterocycle formation, reductive amination, protein degrader formation, biotin tagging, Mitsunobu reaction, Boc protection, Boc deprotection, and fluorination.
• Run initiation: The user scans or selects the pre-filled reagent cartridge, inserts it into the synthesizer, adds the starting material, and presses START.
• Method loading: Scanning the cartridge automatically loads the appropriate reaction method encoded on the cartridge RFID chip.
• Process execution: After initiation, the instrument prepares the starting material and carries out the programmed reaction sequence through the required cartridge compartments or in the reaction vial, depending on the method.
• Product handling: During the run, the platform generates the product and performs the associated isolation and purification steps automatically.
• Preparation for next run: After product collection, the synthesizer performs an automated washing sequence to prepare the instrument for the next synthesis.
• Experiment planning: The platform supports parallel or sequential experiments and routine optimization workflows.

Synple Chem Product and Cartridge Lineup

Chemical Express, with over 23 years of expertise, is the official distributor of Merck and Synple Chem in Thailand. Access Synple Chem’s automated synthesis platform and a wide range of innovative chemical products from leading brands through Chemical Express to enhance your research with reliability and efficiency.