UHPLC-MS LiChrosolv® Solvents by Supelco®: Ultimate Sensitivity and Reliability for Your Analytical Chromatography

Analytical labs require solvents that deliver high sensitivity, low noise, and outstanding reliability for UHPLC-MS, HPLC, and LC-MS. UHPLC-MS LiChrosolv® solvents from Supelco®, under Merck, set a new standard with exceptional UV transmittance, ultra-low impurities, and proven performance, ensuring optimal chromatographic results every time.

Why Choose UHPLC-MS LiChrosolv® Solvents

 
• Highest sensitivity, consistently: UHPLC-MS LiChrosolv® solvents combine excellent resolution with minimized ion suppression and low background signals to deliver clean mass spectra and optimum ionization efficiency for highly sensitive analyses.
 
• Low noise for clearer decisions: Their very low baseline noise and interference reduction support flat, interference-free baselines, helping you distinguish true analyte signals with confidence.
 
• Reliable results across ionization modes: Developed to provide rapid and reliable results in both ESI/APCI positive and negative ionization modes, supporting robust data quality for diverse UHPLC-MS methods.
 
• Confidence backed by controlled impurities: The specified lowest possible limit of PEG impurities in all UHPLC-MS LiChrosolv® solvents helps safeguard data integrity and reduce unexpected signals.
 
• Repeatability you can trust: Consistent ionization efficiency and good repeatability help ensure method robustness from run to run.
 
• Protects your UHPLC workflow: By reducing sources of background and interferences, these solvents can also help extend column lifetime, supporting stable system performance over time.
 
• Built for demanding applications: Designed to meet the highest requirements of UHPLC-MS in research and quality control, including proteomics, metabolomics, and environmental, clinical, food, or industrial testing—providing analytical flexibility without compromising reliability.

Distinctive Qualities for Advanced Analysis

 
• Excellent UV transmittance for analytical flexibility — High UV transparency supports use in UHPLC-UV as well as UHPLC-MS workflows, enabling seamless method selection without changing solvent quality.
 
• Tightly controlled impurity profile — Low particle counts, low acid and alkalinity, and low evaporation residue levels help minimize baseline interferences. In addition, our UHPLC-MS LiChrosolv solvents specify the lowest possible limit of polyethylene glycol (PEG) impurities to enhance confidence in results.
 
• Microfiltered purity — Each solvent is microfiltered at 0.2 µm, contributing to low particulate load to prolong the lifetime of filters and mechanical parts in HPLC systems and reduce the risk of column clogging.
 
• Packaging designed to protect sample integrity — Bottled in borosilicate glass to minimize contamination with metal ions. The lowest levels of trace metal impurities further help to minimize metal ion adduct formation.
 
• Low ionic background with minimized ion suppression — LiChrosolv hypergrade solvents are formulated for LC-MS with low ionic background and minimal ion suppression, meeting modern LC-MS ionization standards while maintaining good repeatability and ionization efficiency in both positive and negative ESI/APCI modes.
 
• Grade options matched to method needs — Available in isocratic and gradient grades, with gradient grades designed to minimize gradient effects. Hypergrade options are suited for fast chromatography and LC-MS.

Performance Standards and Specifications Made Simple

 
• Suitability testing: specified for UHPLC-MS and UHPLC-UV.
 
• ESI/APCI MS specification thresholds:
   
  • ESI/APCI (+): < 2 ppb
   
  • ESI/APCI (−): < 10 ppb
 
• Trace metal impurities: < 5 ppb.
 
• Polyethylene glycol (PEG) impurity check: PEG signal-to-noise ratio < 50.
 
• Filtration: microfiltered through 0.2 µm.

 
• Packaging: borosilicate glass bottles.
 
• Available grades: isocratic and gradient.
 
• Representative UHPLC-MS data (acetonitrile/water system):
   
  • Detected and identified: 1 ppb reserpine, 500 ppt propazine, 4 ppb prednisolone.
   
  • Conditions: gradient 2% to 98% acetonitrile; column Supelco® Ascentis® Express C18, 2 µm, 2.1 × 30 mm; Q-TOF, ESI(+).
 
• Particle counting method: five measurements per sample by single particle counting (RION KS-40BF), light diffraction.

Versatility Across Analytical Applications

 
• Research and quality control: Suitable for UHPLC-MS, HPLC, and LC-MS workflows in both investigative and routine analyses.
 
• Proteomics and metabolomics: Applicable to studies requiring UHPLC-MS performance in ESI/APCI positive and negative ionization modes.
 
• Clinical and environmental testing: Supports MS-based methods across ESI/APCI polarities.
 
• Food testing: Fits UHPLC-MS analyses where positive or negative ESI/APCI modes are employed.
 
• Industrial testing: Addresses MS applications that benefit from operation in either ESI or APCI, in both positive and negative modes.
 
• UHPLC-UV methods: Also specified for UHPLC-UV, enabling use in LC workflows with UV detection.

Available UHPLC-MS LiChrosolv® Solvent Product Range

With over 23 years of expertise, Chemical Express is your authorized distributor for Merck and Supelco®, offering UHPLC-MS LiChrosolv® solvents and more. Enhance your analytical applications by purchasing these reliable products and other related chemical solutions through Chemical Express.