Deviron® C16 & 13-S9 Detergents from Merck: High-Performance Solutions for Biopharma Workflows
Pharmaceutical and biopharmaceutical manufacturing requires detergents that support viral inactivation, environmental safety, and bioprocess compatibility. The Deviron® Detergent Portfolio addresses these needs with solutions designed to support workflows from R&D to production while helping maintain yield and compliance. Explore key benefits and applications of Deviron® detergents for your workflows.
Why choose the Deviron® Detergent Portfolio
- Environmental safety: Designed to avoid harmful degradation products, helping minimize disposal risks and support compliance with environmental regulations.
- High process performance: Supports viral inactivation and cell lysis with performance comparable to or better than benchmark detergents such as Triton™ X-100 and Polysorbate 20.
- Bioprocess compatibility: Does not adversely affect the yield, purity or activity of biopharmaceutical products.
- Removal and detectability: Can be removed efficiently during downstream processing, and trace amounts can be measured using methods such as HPLC-CAD.
Techical Specification of Deviron® Detergent
| Description | Deviron® C16 Detergent 30% solution Emprove® Evolve | Deviron® 13-S9 Detergent Emprove® Expert | Triton™ X-100 Emprove® Expert Ph Eur |
|---|---|---|---|
| Surfactant type | Zwitterionic (pI 8.9) | Non-ionic | Non-ionic |
| Chemical name | N,N-Dimethyltetradecylamin-N-oxide | Alcohols, C11-15-secondary, ethoxylated | 4-(1,1,3,3-tetramethylbutyl) phenol ethoxylated |
| Critical micelle concentration (CMC) | 0.002–0.003% wt (24 °C) | 0.005% wt (24 °C) | 0.013% wt (24 °C) |
| Biodegradability (readily biodegradable: >60% within 28 days) OECD 301 | Readily biodegradable: 88% degradation (OECD 301B) | Readily biodegradable: 74% degradation (OECD 301B) | Substance of Very High Concern as defined by REACH |
| Virus inactivation efficiency LRV ≥ 4 (@ ≥0.5% wt, 15-25 °C) | Better or comparable to benchmark | Better or comparable to benchmark | Benchmark |
| Cell lysis efficiency for viral vector processing | Better or comparable to benchmark | Better or comparable to benchmark | Benchmark |
| Endotoxins removal for plasmid manufacturing: Natrix® Q chromatography membrane/ detergents added to wash buffer supplement | 99.997% removal | 99.969% removal | 99.997% removal |
| Emprove® & M-Clarity™ | Emprove® Evolve MQ400, (ISO9001 or equivalent) | Emprove® Expert MQ500, (IPEC-PQG GMP) | Emprove® Expert MQ500, (IPEC-PQG GMP) |
| Composition | 30% aqueous solution | Pure substance (100%) | Pure substance (100%) |
| Customized certificate of analysis options | Available | Available | Available |
| Toxicology report | Available | Available | NA |
How The Deviron® Detergent Portfolio is used
- R&D workflows: Used to support applications in research and development.
- Process development workflows: Used to support applications in process development.
- Production scale operations: Used to support applications in production scale operations within pharmaceutical and biopharmaceutical manufacturing workflows.
Products in the Deviron® Detergent Portfolio
| Product Name | CAS No. | MQ Level | Pack Size [L] |
|---|---|---|---|
| Deviron® C16 Detergent 30% solution Emprove® Evolve | 3332-27-2 | 400 | 1 |
| Deviron® C16 Detergent 30% solution Emprove® Evolve | 3332-27-2 | 400 | 2.5 |
| Deviron® C16 Detergent 30% solution Emprove® Evolve | 3332-27-2 | 400 | 25 |
| Deviron® 13-S9 Detergent Emprove® Expert | 68131-40-8 | 500 | 1 |
| Deviron® 13-S9 Detergent Emprove® Expert | 68131-40-8 | 500 | 2.5 |
| Deviron® 13-S9 Detergent Emprove® Expert | 68131-40-8 | 500 | 25 |
Chemical Express, with over 23 years of expertise, is the official distributor of Merck in Thailand. Order the Deviron® Detergent Portfolio and related products through Chemical Express to support your bioprocessing needs with reliable, high-quality solutions.
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