γ-Valerolactone (GVL) by Merck – A BioRenewable, Non-Toxic Solvent for Analytical Chromatography and Synthesis

Laboratories and researchers need safer, eco-friendly solvents that deliver consistent results. γ-Valerolactone (GVL) addresses these needs with non-toxic, biodegradable properties and effective performance as a dipolar aprotic solvent. Learn how GVL, a sustainable alternative to NMP and DMF, powers advanced applications in cross-coupling reactions, ATRP polymerization, and peptide synthesis.

Why Choose γ-Valerolactone (GVL)

• γ-Valerolactone (GVL) offers laboratories and researchers a non-toxic and biodegradable solvent choice.
• As a BioRenewable and fully degradable solvent, GVL supports eco-friendly solvent selection in research workflows.
• Its low volatility helps reduce VOC-related solvent impact in laboratory use.
• GVL is considered a sustainable alternative to traditional solvents such as NMP and DMF, and is presented as an alternative for NMP, DMF and DMA.
• Its safer solvent profile makes it a practical option for laboratories seeking safer solvent and auxiliary choices.
• GVL is positioned to deliver consistent results for laboratories and researchers that need effective solvent performance.

Key Features of γ-Valerolactone (GVL)

• Dipolar aprotic solvent
• BioRenewable composition
• Fully degradable profile
• Non-toxic nature
• Water miscibility
• Low volatility and low VOC solvent
• Thermal stability
• No peroxide formation under ambient conditions.
• No hydrolytic behavior under ambient conditions.
• Alternative solvent positioning for NMP, DMF and DMA.

Technical Specifications of γ-Valerolactone (GVL)

• CAS No.: 108-29-2
• Density (g/mL): 1.05 g/mL
• Boiling Point: ~207°
• Melting Point: -31 °

Applications and Usage of γ-Valerolactone (GVL)

• Cross-coupling reactions
• ATRP polymerization
• Replacement of DCM in peptide synthesis
• Green extraction processes: GVL is increasingly being used for green extraction of natural products due to its excellent solvency and sustainability profile.

With over 23 years of expertise, Chemical Express is Thailand’s official Merck distributor, offering γ-Valerolactone (GVL) and related high-quality products. Trust Chemical Express for your solvent and analytical chemistry needs from Merck and other leading brands.