High-Quality Acylcarnitine Reference Materials by Supelco and Cerilliant: Reliable Standards for Newborn Screening & Metabolic Research
Ensuring accurate detection of metabolic disorders is vital for patient care and research. High-quality acylcarnitine reference materials from Supelco and Cerilliant help laboratories meet the growing demand for reliable biomarkers in newborn screening and clinical diagnostics. This page explains how these certified standards fulfill industry requirements for sensitivity, precision, and comprehensive metabolite profiling.
Benefits and Key Features of Supelco® and Cerilliant® High-Quality Acylcarnitine Reference Materials
- Reliable biomarker reference standards: Enable accurate detection of metabolic disorders by providing reference materials for important diagnostic acylcarnitine biomarkers.
- Confidence in newborn screening: Help laboratories implement dependable newborn screening workflows for inborn errors of metabolism.
- Sensitivity and precision: Meet industry requirements for sensitive and precise acylcarnitine analysis in clinical diagnostics and research.
- Comprehensive metabolite profiling: Enable more complete acylcarnitine profiling for metabolic disease testing.
- Broad diagnostic relevance: Support testing strategies used in the diagnosis of carnitine deficiency, fatty acid oxidation defects, and organic acidurias.
Supelco® and Cerilliant® Portfolio Overview
- Supelco® portfolio: High-quality analytical standards and certified reference materials (CRMs) of acylcarnitines.
- Supelco® formats: Native and stable isotope-labeled internal standards, including solution-based multianalyte acylcarnitine CRM mixes.
- Cerilliant® portfolio: CRMs of native and stable isotope-labeled carnitine and acetylcarnitine.
- Cerilliant® formats: Single-component solutions, multi-component solution mixes, and Certified Spiking Solutions® products.
Application and Usage of High-Quality Acylcarnitine Reference Materials in Screening and Metabolic Disease Testing
- Diagnostic biomarker testing: Acylcarnitine reference materials are used in analytical workflows that measure acylcarnitines as diagnostic biomarkers for inherited peroxisomal and mitochondrial oxidation disorders in tissues and body fluids.
- Metabolic disorder assessment: These materials are used in diagnostic testing where abnormal concentrations of specific acylcarnitines indicate carnitine deficiency, fatty acid oxidation defects, and organic acidurias, including carnitine-acylcarnitine translocase deficiency (CACTD) and isobutyryl-CoA dehydrogenase deficiency.
- Newborn screening: Acylcarnitines are used as primary markers on dried blood filter papers (DBS) in newborn screening for the detection of more than 40 different inborn errors of metabolism.
- Mass spectrometry-based metabolic disease detection: The reference materials are suitable for metabolic disease detection by MS, GC/MS, or LC/MS.
- LC-MS/MS screening workflows: Acylcarnitine reference materials are used in LC-MS/MS methods for analyzing acyl-L-carnitines in newborn screening programs and related metabolic testing.
- Chromatographic separation workflows: For more detailed analysis and for measuring closely related acylcarnitine isomers, these materials are used in methods where liquid chromatography is performed before detection.
Acylcarnitines Certified Reference Materials
| Product name | Pack Size |
|---|---|
| Acylcarnitines Mix 1 (C0,C2) | 10.0 mg/mL (each analyte as free base) in methanol |
| Acylcarnitines Mix 2 (C4,iC4,C5,iC5,C6,C8,C10,C12,C14,C18) | 100-200 µg/mL in 90:10 methanol:1% aqueous formic acid |
| Acylcarnitines Mix 3 (C8:1,C10:1,C12:1,C14:1,C14:2,C16:1,C18:1,C18:2) | 100-200 ug/mL in 90:10 methanol:1% aqueous formic acid |
| Acylcarnitines IS Mix 1 (C0,C2) | 1.0 mg/mL each analyte in methanol |
| Acylcarnitines IS Mix 2 (C4,iC5,C6,C8,C10,C12,C14,C18) | 100-200 µg/mL in 90:10 methanol:1% aqueous formic acid |
| Glutaryl-L-Carnitine | 100 µg/mL in 90:10 methanol:1% aqueous formic acid |
| Glutaryl-L-Carnitine-(N-Methyl-D3) | 100 µg/mL in 90:10 methanol:1% aqueous formic acid |
| Palmitoyl-L-Carnitine | 5.0 mg/mL in 90:10 methanol:dmso |
| Palmitoyl-L-Carnitine (N-Methyl-D3) | 500 µg/mL in 90:10 methanol:dmso |
| Propionyl-L-Carnitine | 5.0 mg/mL in 90:10 methanol:dmso |
| Propionyl-L-Carnitine-(N-Methyl-D3) | 500 µg/mL in 90:10 methanol:dmso |
Acylcarnitines Analytical Standards
| Product name | ID | Pack Size |
|---|---|---|
| L-Carnitine hydrochloride | C0 | 10 mg/50 mg |
| O-Acetyl-L-carnitine hydrochloride | C2 | 10 mg/50 mg |
| Propionyl-L-carnitine | C3 | 10 mg/50 mg |
| Butyryl-L-carnitine | C4 | 10 mg/50 mg |
| Isobutyryl-L-carnitine | iC4 | 10 mg/50 mg |
| Valeryl-L-carnitine | C5 | 10 mg/50 mg |
| Isovaleryl-L-carnitine | iC5 | 10 mg/50 mg |
| Hexanoyl-L-carnitine | C6 | 10 mg/50 mg |
| Octanoyl-L-carnitine | C8 | 10 mg/50 mg |
| Decanoyl-L-carnitine | C10 | 10 mg/50 mg |
| Lauroyl-L-carnitine | C12 | 10 mg/50 mg |
| Myristoyl-L-carnitine | C14 | 10 mg/50 mg |
| Palmitoyl-L-carnitine | C16 | 10 mg/50 mg |
| Stearoyl-L-carnitine | C18 | 10 mg/50 mg |
| 2-Methylbutyryl-L-carnitine | 10 mg/50 mg | |
| Malonyl-L-carnitine lithium salt | C3DC | 10 mg/50 mg |
| O-Succinyl-L-carnitine lithium salt | C4DC | 10 mg/50 mg |
| Glutaryl-L-carnitine lithium salt | C5DC | soon available |
| Adipoyl-L-carnitine lithium salt | C6DC | soon available |
| Adipoyl-L-carnitine | C6DC | 10 mg/50 mg |
| Suberoyl-L-carnitine lithium salt | C8DC | 10 mg/50 mg |
| Suberoyl-L-carnitine | C8DC | 10 mg/50 mg |
| Sebacoyl-L-carnitine lithium salt | C10DC | 10 mg/50 mg |
| Methylmalonyl-L-carnitine lithium salt | 10 mg/50 mg | |
| Tigloyl-L-carnitine | C5:1 | 10 mg/50 mg |
| trans-2-Octenoyl-L-carnitine | C8:1 | 10 mg/50 mg |
| trans-2-Decenoyl-L-carnitine | C10:1 | 10 mg/50 mg |
| trans-2-Dodecenoyl-L-carnitine | C12:1 | 10 mg/50 mg |
| trans-2-Tetradecenoyl-L-carnitine | C14:1 | 10 mg/50 mg |
| trans-2-Hexadecenoyl-L-carnitine | C16:1 | 10 mg/50 mg |
| Oleoyl-L-carnitine | C18:1 | 10 mg/50 mg |
| 2-trans,4-cis-Decadienoyl-L-carnitine | C10:2 | soon available |
| cis,cis-5,8-Tetradecanedienoyl-L-carnitine | C14:2 | 10 mg/50 mg |
| cis,cis-9,12-Octadecadienoyl-L-carnitine | C18:2 | 10 mg/50 mg |
| Arachidonyl-L-carnitine | C20:4 | 10 mg/50 mg |
| 3-Methylcrotonyl-L-carnitine | 10 mg/50 mg | |
| [(R)-3-Hydroxybutyryl]-L-carnitine | C4OH | soon available |
| 3-Hydroxyisovaleryl-L-carnitine | iC5OH | 10 mg/50 mg |
| [(3R)-3-Hydroxyhexanoyl]-L-carnitine | C6OH | 10 mg/50 mg |
| [(3R)-3-Hydroxyoctanoyl]-L-carnitine | C8OH | 10 mg/50 mg |
| [(3R)-3-Hydroxydecanoyl]-L-carnitine | C10OH | 10 mg/50 mg |
| [(3R)-3-Hydroxydodecanoyl]-L-carnitine | C12OH | 10 mg/50 mg |
| [(3R)-3-Hydroxytetradecanoyl]-L-carnitine | C14OH | 10 mg/50 mg |
| [(3R)-3-Hydroxyhexadecanoyl]-L-carnitine | C16OH | 10 mg/50 mg |
| [(3R)-3-Hydroxyoctadecanoyl]-L-carnitine | C18OH | 10 mg/50 mg |
| [(3R)-3-Hydroxy-cis-tetradec-9-enoyl]-L-carnitine | C14:1OH | 1 mg/10 mg |
| [(3R)-3-Hydroxy-cis-hexadec-9-enoyl]-L-carnitine | C16:1OH | 1 mg/10 mg |
| [(3R)-3-Hydroxy-cis-octadec-9-enoyl]-L-carnitine | C18:1OH | 1 mg/10 mg |
| [(3R)-3-Hydroxy-cis,cis-octadeca-9,12-dienoyl]-L-carnitine | C18:2OH | soon available |
| trans-Cinnamoyl-L-carnitine | C9Ar | 10 mg/50 mg |
Stable isotope labeled Acylcarnitines
| Product name | ID | Pack Size |
|---|---|---|
| L-Carnitine-(N-methyl-d3) | C0-d3 | 1 mg/5 mg/10 mg |
| L-Carnitine-(N,N,N,-trimethyl-13C3) | C0-13C3 | 1 mg/10 mg |
| L-Carnitine-(N,N,N-trimethyl-d9) | C0-d9 | 1 mg/5 mg/10 mg |
| Acetyl-L-carnitine-(N-methyl-d3) | C2-d3 | 1 mg/5 mg/10 mg |
| Propionyl-L-carnitine-(N-methyl-d3) | C3-d3 | 1 mg/5 mg/10 mg |
| Butyryl-L-carnitine-(N-methyl-d3) | C4-d3 | 1 mg/5 mg/10 mg |
| Isobutyryl-L-carnitine-(N,N,N-trimethyl-d9) | iC4-d9 | 1 mg/10 mg |
| Valeryl-L-carnitine-(N-methyl-d3) | C5-d3 | 1 mg/10 mg |
| Isovaleryl-L-carnitine-(N,N,N-trimethyl-d9) | iC5-d9 | 1 mg/5 mg/10 mg |
| Hexanoyl-L-carnitine-(N-methyl-d3) | C6-d3 | 1 mg/5 mg/10 mg |
| Octanoyl-L-carnitine-(N-methyl-d3) | C8-d3 | 1 mg/5 mg/10 mg |
| Decanoyl-L-carnitine-(N-methyl-d3) | C10-d3 | 1 mg/5 mg/10 mg |
| Lauroyl-L-carnitine-(N,N,N-trimethyl-d9) | C12-d9 | 1 mg/5 mg/10 mg |
| Myristoyl-L-carnitine-(N,N,N-trimethyl-d9) | C14-d9 | 1 mg/5 mg/10 mg |
| Palmitoyl-L-carnitine-(N-methyl-d3) | C16-d3 | 1 mg/5 mg/10 mg |
| Stearoyl-L-carnitine-(N-methyl-d3) | C18-d3 | 1 mg/5 mg/10 mg |
| Malonyl-L-carnitine-(N-methyl-d3) lithium salt | C3DC-d3 | 1 mg/5 mg/10 mg |
| Succinyl-L-carnitine-(N-methyl-d3) lithium salt | C4DC-d3 | 1 mg/5 mg/10 mg |
| Glutaryl-L-carnitine-(N-methyl-d3) lithium salt | C5DC-d3 | 1 mg/5 mg/10 mg |
| Adipoyl-L-carnitine-(N-methyl-d3) lithium salt | C6DC-d3 | 1 mg/5 mg/10 mg |
| Suberoyl-L-carnitine-(N-methyl-d3) lithium salt | C8DC-d3 | 1 mg/5 mg/10 mg |
| Sebacoyl-L-carnitine-(N-methyl-d3) lithium salt | C10DC-d3 | 1 mg/5 mg/10 mg |
| Methylmalonyl-L-carnitine-(N-methyl-d3) lithium salt | 1 mg/5 mg | |
| 3-Hydroxyisovaleryl-L-carnitine-(N-methyl-d3) | iC5OH-d3 | 1 mg/5 mg |
| [(3R)-3-Hydroxydecanoyl]-L-carnitine-(N-methyl-d3) | C10OH-d3 | 1 mg/10 mg |
| [(R)-3-Hydroxyhexadecanoyl]-L-carnitine-(N-methyl-d3) | C16OH-d3 | 1 mg/5 mg/10 mg |
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