High-Quality Organic Acids Reference Materials by Merck: Precision Standards for Metabolic Analysis & Diagnostics
Accurate metabolic analysis is critical in detecting inborn errors and supporting clinical diagnostics. Organic acid disorders require precise identification of physiologic intermediates, demanding high-quality reference materials of organic acids. This page highlights Merck’s certified organic acid standards, offering both native and stable isotope-labeled options tailored for reliable preparation of calibrators and controls for GC/MS and LC/MS in clinical and research laboratories.
Why choose high-quality reference materials of organic acids
- Accurate metabolic analysis: Supports precise analysis of physiologic intermediates involved in a variety of metabolic pathways.
- Reliable detection of inborn errors of metabolism: Suitable for use in the detection of inborn errors of metabolism by GC/MS or LC/MS.
- Diagnostic support: Helps enable organic acids analysis used routinely in diagnostic tests and newborn screening programs.
- Preparation of essential analytical materials: Provides dependable standards for building and validating organic acids calibration curves and quality control samples.
- Workflow flexibility: Supports laboratories using either GC/MS or LC/MS for organic acids analysis.
What these organic acids reference materials include
- Analytical Standards and Certified Reference Materials: High-quality analytical standards and certified reference materials (CRMs) of organic acids.
- Internal Standard Options: Native and stable isotope-labeled internal standards included within the organic acids reference materials portfolio.
- Preparation Suitability: Suitable for preparing calibrators, controls, and internal standards across clinical and research workflows.
Applications and usage of organic acid reference materials
- Use as certified calibrators, quality control samples, and internal standards in organic acids analysis by GC/MS and LC/MS.
- Detection of inborn errors of metabolism by GC/MS or LC/MS.
- Support for routine organic acids testing in clinical diagnostic workflows.
- Integration into organic acids panels used in newborn screening programs.
Organic Acids Certified Reference Material
| Potential New Products | Pack Size |
|---|---|
| Methylmalonic acid | 1.0 mg/mL in acetonitrile |
| Methyl-D3-malonic acid | 1.0 mg/mL in acetonitrile |
| Methylmalonic acid-13C4 | 100 µg/mL in acetonitrile |
| Valproic acid | 1.0 mg/mL in methanol |
| Valproic acid-D6 | 1.0 mg/mL in methanol |
Organic Acids Analytical Standard
| Potential New Products | Pack Size |
|---|---|
| Adipic acid | 100 mg |
| α-Aminoadipic acid (DL-2-Aminoadipic acid) | 10 mg/50 mg |
| α-Aminoadipic acid (L-2-Aminoadipic acid) | 10 mg/50 mg |
| γ-Aminobutyric acid | 250 mg |
| γ-Aminobutyric acid | 50 mg |
| α-Aminobutyric acid (DL-2-Aminobutyric acid) | 10 mg/50 mg |
| β-Aminoisobutyric acid (L-3-Aminoisobutyric acid) | 10 mg/50 mg |
| L-Argininosuccinic acid lithium salt | 10 mg/50 mg |
| Aspartic acid | 100 mg |
| Butyric acid | 100 mg |
| Butyric acid | 100 mL |
| Butyric acid | 5 mL |
| 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid | 10 mg/50 mg |
| Citric acid | 500 mg |
| Citric acid | 100 mg |
| 3-Dehydroquinic acid lithium salt | 10 mg/50 mg |
| 3-Deoxy-2-keto-6-phosphogluconic acid lithium salt | 10 mg/50 mg |
| 3-Deoxy-D-arabino-hexonic acid lithium salt | 10 mg/50 mg |
| 4-Deoxy-D-erythronic acid | 10 mg/50 mg |
| 4-Deoxy-L-erythronic acid | 10 mg/50 mg |
| N¹,N¹²-Diacetylspermine hydrochloride | 50 mg/100 mg |
| (2R,3S)-2,3-dihydroxybutanoic acid | 10 mg/50 mg |
| 2,4-Dihydroxybutanoic acid | 10 mg/50 mg |
| (2S,3R)-2,3-dihydroxybutanoic acid | 10 mg/50 mg |
| DL-3,3-Dimethylmalic acid | 10 mg/50 mg |
| (2RS)-2-Ethyl-2-methylpentanoic acid | 50 mg |
| 3-Ethylmalic acid | 10 mg/50 mg |
| Ethylmalonic acid | 10 mg/50 mg |
| Ferulic acid | 50 mg |
| Ferulic acid | 100 mg |
| Fumaric acid | 100 mg |
| Fumarylacetone | 10 mg/50 mg |
| Glutaconic acid | 10 mg/50 mg |
| Glutaric acid | 100 mg |
| Glutaric semialdehyde | 10 mg/50 mg |
| L-Glyceric acid sodium salt | 10 mg/50 mg |
| Hippuric acid | 10 mg/50 mg |
| Hippuric acid-(phenyl-¹³C₆) | 10 mg/50 mg |
| Homogentisic acid | 10 mg/50 mg |
| Homovanillic acid | 25 mg |
| 4-hydroxy-3,3-dimethyl-2-oxo-butanoic acid (2-Dehydropantoic acid) | 10 mg/50 mg |
| DL-4-Hydroxy-2-ketoglutaric acid lithium salt | 10 mg/50 mg |
| 2-Hydroxy-3-methylvaleric acid, mixture of diastereomers | 10 mg/50 mg |
| 2-Hydroxyadipic acid | 10 mg/50 mg |
| (R)-3-Hydroxybutyric acid | 10 mg/50 mg |
| 3-Hydroxyglutaric acid | 10 mg/50 mg |
| D-α-Hydroxyglutaric acid disodium salt (D-2-Hydroxyglutaric acid) | 10 mg/50 mg |
| L-α-Hydroxyglutaric acid disodium salt (L-2-Hydroxyglutaric acid) | 10 mg/50 mg |
| D-α-Hydroxyglutaric acid-¹³C₅ disodium salt ([¹³C₅]-D-2-Hydroxyglutaric acid) | 1 mg/10 mg |
| L-α-Hydroxyglutaric acid-¹³C₅ disodium salt ([¹³C₅]-L-2-Hydroxyglutaric acid) | 1 mg/10 mg |
| 5-Hydroxyindole-3-acetic acid (5HIAA) | 10 mg/50 mg |
| Sodium (R)-β-hydroxyisobutyrate | 10 mg/50 mg |
| 4-Hydroxyisovaleric acid | 10 mg/50 mg |
| 2-(Hydroxymethyl)butyric acid sodium salt | 10 mg/50 mg |
| 3-(4-Hydroxyphenyl)-DL-lactic acid-¹³C₉ | 1 mg/10 mg |
| 3-(3-Hydroxyphenyl)propionic acid | 10 mg/50 mg/250 mg |
| (2RS)-2-(4-Hydroxyphenyl)propionic acid | 10 mg/50 mg/250 mg |
| 3-(3-Hydroxyphenyl)-3-hydroxypropanoic acid | 10 mg/50 mg |
| 4-Hydroxyphenylacetic acid | 10 mg/50 mg |
| 4-Hydroxyphenylpyruvic acid IS (4-Hydroxyphenylpyruvic acid-¹³C₉) | 1 mg/10 mg |
| Isovaleric acid | 1 mL/5 mL |
| 2-Keto-3-deoxy-D-galactonic acid lithium salt | 10 mg |
| α-Ketoglutaric acid / 2-Ketoglutaric acid | 10 mg/50 mg |
| Kynurenic acid | 10 mg/50 mg |
| L-Kynurenine | 10 mg/50 mg |
| L-(+)-Lactic acid | 100 mg |
| Maleic acid | 1 g |
| Malic acid | 100 mg |
| Malonic acid | 100 mg |
| (R) 2-Methyl-3-ureidopropionic acid | 10 mg/50 mg |
| (Z)-3-Methylglutaconic acid | 10 mg/50 mg/250 mg |
| (E)-3-Methylglutaconic acid | 10 mg/50 mg/250 mg |
| 3-Methylglutaconic acid | 10 mg/50 mg |
| (E)-2-Methylglutaconic acid | 10 mg/50 mg |
| (Z)-2-Methylglutaconic acid | 10 mg/50 mg |
| 3-Methylglutaric acid-¹³C₄ (3-Methyl-¹³C-glutaric acid-1,2,3-¹³C₃) | 1 mg/5 mg |
| (2RS,3SR)-2-Methylisocitric acid | 10 mg/50 mg |
| 3-Methylmalic acid | 10 mg/50 mg |
| 2-Methyl-trans-aconic acid | 10 mg/50 mg |
| (RS)-Mevalonic acid | 5 mg |
| (S)-Mevalonic acid lithium salt | 10 mg/50 mg |
| (±)-Mevalonic acid-d₃ | 1 mg/10 mg |
| trans,trans-Muconic acid-¹³C₆ | 1 mg/10 mg |
| Octanoic acid | 50 mg |
| Octanoic acid | 5 mL |
| trans-2-Octenedioic acid (2-Octene-1,8-dioic acid) | 10 mg/50 mg |
| L-Ornithine | 100 mg |
| 2-Oxoadipic acid | 10 mg/50 mg |
| Phenylpyruvic acid | 100 mg |
| Propionic acid | 1 mL/5 mL |
| 3-Propylmalic acid | 10 mg/50 mg |
| Pyroglutamic acid; L-Proline | 100 mg |
| Succinic acid | 100 mg |
| 3-Sulfopyruvic acid | 10 mg/50 mg |
| (±)-Ureidoglycolic acid sodium salt | 10 mg/50 mg/250 mg |
| DL-3-Ureidoisobutyric acid | 10 mg/50 mg |
| cis-Vaccenic acid | 10 mg/100 mg |
| DL-Vanillactic acid | 10 mg/50 mg/250 mg |
| Vanillic acid | 50 mg |
| Vanillylmandelic acid | 25 mg |
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