{"id":10480,"date":"2026-03-19T17:28:24","date_gmt":"2026-03-19T10:28:24","guid":{"rendered":"https:\/\/chemicalexpressth.com\/?p=10480"},"modified":"2026-08-11T15:40:38","modified_gmt":"2026-08-11T08:40:38","slug":"virusexpress-lentiviral-production-platform-merck","status":"publish","type":"post","link":"https:\/\/chemicalexpressth.com\/th\/articles\/product-guide-articles\/virusexpress-lentiviral-production-platform-merck\/","title":{"rendered":"VirusExpress\u00ae Lentiviral Production Platform by Merck: Scalable Lentivirus Manufacturing for Gene Therapy"},"content":{"rendered":"<style>  .chx-standalone-article h1 {       color: #222 !important;       line-height: 1.2 !important;       font-weight: bold !important;       text-align: center !important;       margin-top: 40px !important;       margin-bottom: 30px !important;      text-transform: none !important;   }  .chx-standalone-article h2 {      color: #24326d !important;      font-weight: bold !important;      text-transform: none !important; 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}  }<\/style>\n<div class=\"chx-standalone-article\">\n<div data-elementor-type=\"wp-post\" data-elementor-id=\"10480\" class=\"elementor elementor-10480\" data-elementor-post-type=\"post\">\n<div class=\"elementor-element elementor-element-5aa3af06 e-flex e-con-boxed e-con e-parent\" data-id=\"5aa3af06\" data-element_type=\"container\" data-e-type=\"container\">\n<div class=\"e-con-inner\">\n<div class=\"elementor-element elementor-element-65471e0a elementor-widget elementor-widget-text-editor\" data-id=\"65471e0a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n<div class=\"elementor-widget-container\">\n<h1>VirusExpress\u00ae Lentiviral Production Platform by Merck: Scalable Lentivirus Manufacturing for Gene Therapy<\/h1>\n<div style=\"margin-bottom: 32px; text-align: center;\"><img decoding=\"async\" class=\"lazyload\" style=\"width: 100%; max-width: 800px; height: auto; border-radius: 0px !important;\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/chemicalexpressth.com\/wp-content\/uploads\/2026\/03\/375_250-milliporesigma.jpg\" alt=\"VirusExpress\u00ae Lentiviral Production Platform by Merck: Scalable Lentivirus Manufacturing for Gene Therapy\" \/><noscript><img decoding=\"async\" class=\"lazyload lazyload\" style=\"width: 100%; max-width: 800px; height: auto; border-radius: 0px !important;\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/chemicalexpressth.com\/wp-content\/uploads\/2026\/03\/375_250-milliporesigma.jpg\" alt=\"VirusExpress\u00ae Lentiviral Production Platform by Merck: Scalable Lentivirus Manufacturing for Gene Therapy\" \/><noscript><img decoding=\"async\" class=\"lazyload lazyload lazyload\" style=\"width: 100%; max-width: 800px; height: auto; border-radius: 0px !important;\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/chemicalexpressth.com\/wp-content\/uploads\/2026\/03\/375_250-milliporesigma.jpg\" alt=\"VirusExpress\u00ae Lentiviral Production Platform by Merck: Scalable Lentivirus Manufacturing for Gene Therapy\" \/><noscript><img data-src=\"https:\/\/chemicalexpressth.com\/wp-content\/uploads\/2026\/03\/375_250-milliporesigma.jpg\" decoding=\"async\" class=\"lazyload lazyload lazyload\" style=\"width: 100%; max-width: 800px; height: auto; border-radius: 0px !important;\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" alt=\"VirusExpress\u00ae Lentiviral Production Platform by Merck: Scalable Lentivirus Manufacturing for Gene Therapy\" \/><noscript><img decoding=\"async\" class=\"lazyload lazyload lazyload\" style=\"width: 100%; max-width: 800px; height: auto; border-radius: 0px !important;\" src=\"https:\/\/chemicalexpressth.com\/wp-content\/uploads\/2026\/03\/375_250-milliporesigma.jpg\" alt=\"VirusExpress\u00ae Lentiviral Production Platform by Merck: Scalable Lentivirus Manufacturing for Gene Therapy\"><\/noscript><\/noscript><\/noscript><\/noscript><\/div>\n<p>Gene therapy development requires high-yield, scalable lentiviral vector production that meets strict quality standards. The VirusExpress\u00ae Lentiviral Production Platform addresses these demands with a transfection-based, suspension-adapted HEK293T cell system, chemically defined medium, and proven scalability at 50\u00a0L, supporting a streamlined path from research to clinical application.<\/p>\n<h2>Why Choose the VirusExpress\u00ae Lentiviral Production Platform<\/h2>\n<ul>\n<li><strong>Faster process advancement:<\/strong> Reduces time in process development and scale-up by approximately 40%.<\/li>\n<li><strong>Proven manufacturing performance:<\/strong> Demonstrates proven process performance at 50 L scale with functional titer exceeding 4 \u00d7 10<sup>7<\/sup> TU\/mL.<\/li>\n<li><strong>Accelerated therapy timelines:<\/strong> Supports faster delivery of therapy to patients.<\/li>\n<li><strong>Operational flexibility:<\/strong> Can be implemented in your own facilities or through contract manufacturing capabilities.<\/li>\n<li><strong>Regulatory support:<\/strong> Provides robust quality documentation to support regulatory filings and commercialization.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h2>VirusExpress\u00ae Lentiviral Production Platform: Components and Key Features<\/h2>\n<ul>\n<li><strong>Upstream production architecture:<\/strong> Transfection-based solution configured for lentiviral upstream production.<\/li>\n<li><strong>Cell line component:<\/strong> Suspension-adapted 293T lentiviral production cells form the cell line element of the platform for production of lentiviral vectors for gene therapy applications.<\/li>\n<li><strong>HEK293T Cell Characteristics:<\/strong> HEK293T VirusExpress\u00ae Cells grow in suspension to high cell density and viability with low doubling time.<\/li>\n<li><strong>Transfection compatibility:<\/strong> HEK293T VirusExpress\u00ae Cells were selected for higher lentivirus production using a PEI-based transient transfection method.<\/li>\n<li><strong>Medium Component:<\/strong> EX-CELL\u00ae CD HEK293 Viral Vector Medium is a chemically defined, animal component free medium without L-glutamine.<\/li>\n<li><strong>Process Documentation:<\/strong> Comprehensive user protocols guide the workflow from seed train through at scale transfection and virus production.<\/li>\n<li><strong>Cell Bank Status:<\/strong> The cell bank is GMP banked and fully characterized in accordance with FDA cGMP regulations.<\/li>\n<li><strong>Safety Testing:<\/strong> HEK293T VirusExpress\u00ae Cells are adventitious agent tested.<\/li>\n<li><strong>Regulatory support documentation:<\/strong> The platform includes full traceability and quality documentation to support regulatory filings and commercialization.<\/li>\n<li><strong>Use rights:<\/strong> Licenses are available for research, clinical, and commercial use, depending on the phase of gene therapy development.<\/li>\n<li><strong>Manufacturing Access:<\/strong> The platform can be used within your own facilities or through contract manufacturing capabilities.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h2>VirusExpress\u00ae Lentiviral Production Platform: Technical Specifications<\/h2>\n<ul>\n<li><strong>Proven process scale:<\/strong> 50 L<\/li>\n<li><strong>Functional titer:<\/strong> exceeding 4 \u00d7 10<sup>7<\/sup> TU\/mL<\/li>\n<li><strong>Cell storage temperature:<\/strong> -196 \u00b0C in liquid N2 vapor phase<\/li>\n<li><strong>Medium storage temperature:<\/strong> 2 to 8 \u00b0C<\/li>\n<li><strong>EX-CELL\u00ae CD HEK293 Viral Vector Medium package size:<\/strong> 1000 mL in bottle<\/li>\n<li><strong>EX-CELL\u00ae CD HEK293 Viral Vector Medium package size:<\/strong> 10 L in bag<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h2>Applications and Intended Use of the VirusExpress\u00ae Lentiviral Production Platform<\/h2>\n<ul>\n<li>Lentiviral upstream production: Supports transfection-based lentiviral upstream production for suspension workflows.<\/li>\n<li><strong>Gene therapy vector manufacturing:<\/strong> Supports production of lentiviral vectors for gene therapy applications using optimized 293T Lentiviral Production Cells.<\/li>\n<li>Research to clinical application: Can be applied across gene therapy development needs with licenses available for research, clinical, and commercial use.<\/li>\n<li><strong>Process progression:<\/strong> Supports workflows from seed train through at-scale transfection and virus production, with comprehensive user protocols for scale-up guidance.<\/li>\n<li><strong>Regulatory-supported programs:<\/strong> Suitable for programs requiring documentation to support regulatory filings and commercialization of gene-modified cell or gene therapies.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h2>Products Included in the VirusExpress\u00ae Lentiviral Production Platform<\/h2>\n<div class=\"res-table-wrapper\">\n<table>\n<tbody>\n<tr style=\"background-color: #24326d;\">\n<th><b><span style=\"color: #ffffff;\">Product Description<\/span><\/b><\/th>\n<th><b><span style=\"color: #ffffff;\">Storage Temperature<\/span><\/b><\/th>\n<th><b><span style=\"color: #ffffff;\">Package Size<\/span><\/b><\/th>\n<\/tr>\n<tr>\n<td>VirusExpress\u00ae 293T Lentiviral Production Cells*<\/td>\n<td>-196 \u00b0C (Liquid N2 vapor phase)<\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>EX-CELL\u00ae CD HEK293 Viral Vector Medium, chemically defined, animal component-free, without L-glutamine, liquid, sterile-filtered, suitable for cell culture<\/td>\n<td>2-8 \u00b0C<\/td>\n<td>1000 mL in bottle<\/td>\n<\/tr>\n<tr>\n<td>EX-CELL\u00ae CD HEK293 Viral Vector Medium, chemically defined, animal component-free, without L-glutamine, liquid, sterile-filtered, suitable for cell culture<\/td>\n<td>2-8 \u00b0C<\/td>\n<td>10 L in bag<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p>With over 23 years of expertise, Chemical Express is the official distributor for Merck in Thailand, offering the VirusExpress\u00ae Lentiviral Production Platform and related solutions. Rely on our trusted service to obtain Merck and partner products, ensuring your bioprocessing needs are fully met with quality and regulatory assurance.<\/p>\n<div style=\"text-align: center; margin-top: 64px; padding-bottom: 60px;\">\n<h3 style=\"margin-bottom: 8px;\">Have questions about the VirusExpress\u00ae Lentiviral Production Platform or ready to order?<\/h3>\n<p>Simply fill out our Inquiry Form or chat with us instantly on Line using the buttons below.<br \/>We&#8217;re here to help!<\/p>\n<div style=\"display: flex; justify-content: center; align-items: center; gap: 16px; flex-wrap: wrap; margin-bottom: 20px;\"><a style=\"display: inline-flex; align-items: center; justify-content: center; padding: 14px 28px; background: #0b5ed7; color: #ffffff; text-decoration: none; border-radius: 8px; font-weight: 600; font-size: 16px; line-height: 1; white-space: nowrap;\" href=\"https:\/\/forms.zohopublic.com\/chatchawan1\/form\/WebsiteLeadFormINQUIRYFORM\/formperma\/oH9iL6pKdhH5WoJRahWoHuc5H_68uNoURPhu7cgU_rY?utm_source=n8n&amp;utm_medium=article&amp;utm_campaign=content2026_03_Product&amp;utm_content=virusexpress-lentiviral-production-platform-merck&amp;utm_term=inquiry_form&amp;utm_id=CONTENT_2026_03_Product\" target=\"_blank\" rel=\"noopener noreferrer\" data-track=\"enquiry_cta\" data-intent=\"lead\">Submit Inquiry<\/a> <a style=\"display: inline-flex; align-items: center; justify-content: center; padding: 14px 28px; background: #06c755; color: #ffffff; text-decoration: none; border-radius: 8px; font-weight: 600; font-size: 16px; line-height: 1; white-space: nowrap;\" href=\"https:\/\/liff.line.me\/2004801212-fkTuG4m6?utm_source=website&#038;utm_medium=article&#038;utm_campaign=product_guide_2026&#038;utm_content=product_guide_article&#038;utm_term=add_line&#038;utm_id=product_guide_2026\" target=\"_blank\" rel=\"noopener noreferrer\" data-track=\"line_cta\" data-intent=\"add_line\">Add LINE<\/a><\/div>\n<\/div>\n<p>&#8220;`\t\t\t\t\t\t\t\t<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Order VirusExpress\u00ae Lentiviral Production Platform from Chemical Express, the official distributor of Merck in Thailand. 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