{"id":11010,"date":"2026-03-29T14:26:12","date_gmt":"2026-03-29T07:26:12","guid":{"rendered":"https:\/\/chemicalexpressth.com\/?p=11010"},"modified":"2026-08-11T15:45:34","modified_gmt":"2026-08-11T08:45:34","slug":"lichroprep-sorbent-pharma-chromatography-merck","status":"publish","type":"post","link":"https:\/\/chemicalexpressth.com\/th\/articles\/product-guide-articles\/lichroprep-sorbent-pharma-chromatography-merck\/","title":{"rendered":"LiChroprep\u00ae Sorbent by Merck: High-Efficiency Silica Chromatography Resins for Reliable Peptide and API Purification"},"content":{"rendered":"<style>  .chx-standalone-article h1 {       color: #222 !important;       line-height: 1.2 !important;       font-weight: bold !important;       text-align: center !important;       margin-top: 40px !important;       margin-bottom: 30px !important;      text-transform: none !important;   }  .chx-standalone-article h2 {      color: #24326d !important;      font-weight: bold !important;      text-transform: none !important;      margin-top: 35px !important;      margin-bottom: 20px !important;  }  .chx-standalone-article .res-table-wrapper {       width: 100% !important;       overflow-x: auto !important;       -webkit-overflow-scrolling: touch !important;       margin-bottom: 25px !important;   }  .chx-standalone-article table {       min-width: 600px !important;       width: 100% !important;   }  @media only screen and (min-width: 1025px) {    .chx-standalone-article h1 { font-size: 30px !important; }    .chx-standalone-article h2 { font-size: 24px !important; }  }  @media only screen and (max-width: 1024px) {    .chx-standalone-article h1 { font-size: 22px !important; margin-top: 30px !important; margin-bottom: 25px !important; }    .chx-standalone-article h2 { font-size: 20px !important; }  }  @media only screen and (max-width: 480px) {    .chx-standalone-article h1 { font-size: 15px !important; margin-top: 20px !important; margin-bottom: 20px !important; }    .chx-standalone-article h2 { font-size: 18px !important; }  }<\/style>\n<div class=\"chx-standalone-article\">\n<h1>LiChroprep\u00ae Sorbent by Merck: High-Selective Silica Chromatography Resins for Reproducible Peptide and API Purification<\/h1>\n<div style=\"margin-bottom: 32px; text-align: center;\">  <img decoding=\"async\" class=\"lazyload\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/chemicalexpressth.com\/wp-content\/uploads\/2026\/03\/image-203.jpg\"        alt=\"LiChroprep\u00ae Sorbent by Merck: High-Selective Silica Chromatography Resins for Reproducible Peptide and API Purification\"        style=\"width: 100%; max-width: 800px; height: auto; border-radius: 0px !important;\"><\/div>\n<p>Purifying peptides and APIs with speed, efficiency and reproducibility is crucial in pharma and biopharma manufacturing. LiChroprep\u00ae Sorbents by Merck provide excellent selectivity and are described as a very efficient and economic alternative for almost all preparative chromatography purification challenges, designed to meet the special requirements of customers&#8217; manufacturing processes. This page details the benefits, technical features and product options of LiChroprep\u00ae RP and Si chromatography resins for peptide and API purification.<\/p>\n<h2>Benefits of LiChroprep\u00ae Sorbent<\/h2>\n<ul>\n<li><strong>Reproducible purification results:<\/strong> Delivers consistent, reproducible separation performance across peptide purification processes, ensuring reliable outcomes batch after batch.<\/li>\n<li><strong>High purity output:<\/strong> Achieves high levels of purity in a rapid and economical manner, making it suited for purifying valuable compounds in research, pilot plant operation and production.<\/li>\n<li><strong>Excellent selectivity and efficiency:<\/strong> Provides excellent selectivity and separation efficiency, enabling precise isolation of target compounds from complex mixtures.<\/li>\n<li><strong>Cost-effective API polishing:<\/strong> LiChroprep\u00ae Si offers a cost-effective and reliable solution for polishing biopharmaceutical and pharmaceutical APIs without compromising quality.<\/li>\n<li><strong>Large batch size support:<\/strong> Supports large batch sizes of up to 200 kg in the modification step.<\/li>\n<li><strong>High performance and high permeability:<\/strong> The narrow, well-defined particle size distribution contributes to high performance and high permeability.<\/li>\n<li><strong>Economical alternative for preparative chromatography:<\/strong> Irregularly shaped sorbents are a very efficient and an economic alternative for almost all preparative chromatography purification challenges.<\/li>\n<\/ul>\n<h2>Features of LiChroprep\u00ae Sorbent<\/h2>\n<ul>\n<li><strong>Silica gel matrix:<\/strong> Totally porous, irregularly shaped silica gel particles form the base matrix of LiChroprep\u00ae sorbents, with good separation performance and sufficient stability at reasonable cost.<\/li>\n<li><strong>Particle size classification:<\/strong> Particles are tightly classified into three defined ranges: 15\u201325 \u03bcm, 25\u201340 \u03bcm, and 40\u201363 \u03bcm.<\/li>\n<li><strong>Available product variants:<\/strong> Available as LiChroprep\u00ae RP-18, LiChroprep\u00ae RP-8, and LiChroprep\u00ae Si 60.<\/li>\n<li><strong>Homogeneous matrix structure:<\/strong> The silica gel matrix is reproducible and homogeneous across production batches.<\/li>\n<li><strong>Narrow particle size distribution:<\/strong> Each particle size range is characterized by a well-defined quality factor (d90\/d10) to ensure consistent classification.<\/li>\n<li><strong>Ready-to-use column format:<\/strong> LiChroprep\u00ae is available in prepacked, stainless steel Hibar\u00ae 250-25 mm columns for immediate use.<\/li>\n<li><strong>Bulk pack format:<\/strong> Also supplied in various bulk pack sizes to support preparative and production-scale operations.<\/li>\n<\/ul>\n<h2>Technical Specifications of LiChroprep\u00ae Sorbent<\/h2>\n<div class=\"res-table-wrapper\">\n<table style=\"width:100%; border-collapse: collapse; font-size: 14px;\">\n<thead>\n<tr style=\"background-color: #24326D;\">\n<th style=\"color: white; font-weight: bold; padding: 10px; border: 1px solid #ccc; text-align: left;\">Parameter<\/th>\n<th style=\"color: white; font-weight: bold; padding: 10px; border: 1px solid #ccc; text-align: center;\">LiChroprep\u00ae RP-18<br \/>15\u201325 \u03bcm<\/th>\n<th style=\"color: white; font-weight: bold; padding: 10px; border: 1px solid #ccc; text-align: center;\">LiChroprep\u00ae RP-18<br \/>25\u201340 \u03bcm<\/th>\n<th style=\"color: white; font-weight: bold; padding: 10px; border: 1px solid #ccc; text-align: center;\">LiChroprep\u00ae RP-18<br \/>40\u201363 \u03bcm<\/th>\n<th style=\"color: white; font-weight: bold; padding: 10px; border: 1px solid #ccc; text-align: center;\">Method<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #ccc;\">Particle size range d50 [\u03bcm]<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">18\u201325<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">30\u201335<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">55\u201365<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">Laser diffraction<\/td>\n<\/tr>\n<tr style=\"background-color: #f2f2f2;\">\n<td style=\"padding: 8px; border: 1px solid #ccc;\">Quality factor d90\/d10<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">\u22644.0<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">\u22645.0<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">\u22644.0<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\"><\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #ccc;\">Mean pore size [nm]<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">10<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">10<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">10<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">N\u2082 adsorption (BET)<\/td>\n<\/tr>\n<tr style=\"background-color: #f2f2f2;\">\n<td style=\"padding: 8px; border: 1px solid #ccc;\">Carbon content [weight %]<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">\u226515<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">\u226515<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">\u226515<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">CHN analysis<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #ccc;\">Iron content [weight %]<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">\u22640.02<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">\u22640.02<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">\u22640.02<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\"><\/td>\n<\/tr>\n<tr style=\"background-color: #f2f2f2;\">\n<td style=\"padding: 8px; border: 1px solid #ccc;\">Specific pore volume [mL\/g]<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">0.95\u20131.03<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">0.95\u20131.03<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">0.95\u20131.03<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">N\u2082 adsorption (BET)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #ccc;\">Specific surface area [m\u00b2\/g]<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">330\u2013380<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">330\u2013380<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">330\u2013380<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">N\u2082 adsorption (BET)<\/td>\n<\/tr>\n<tr style=\"background-color: #f2f2f2;\">\n<td style=\"padding: 8px; border: 1px solid #ccc;\">Surface coverage [\u03bcmol\/m\u00b2]<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">3.0<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">3.0<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">3.0<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\"><\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #ccc;\">Elutables [weight %]<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">\u22640.10<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">\u22640.10<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">\u22640.10<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\"><\/td>\n<\/tr>\n<tr style=\"background-color: #f2f2f2;\">\n<td style=\"padding: 8px; border: 1px solid #ccc;\">Bulk density [g\/mL]<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">0.39<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">0.44<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">0.48<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\"><\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #ccc;\">Packing density [g\/mL]<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">0.51<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">0.52<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">0.60<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\"><\/td>\n<\/tr>\n<tr style=\"background-color: #f2f2f2;\">\n<td style=\"padding: 8px; border: 1px solid #ccc;\"><strong>Selectivity<\/strong><\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc;\"><\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc;\"><\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc;\"><\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc;\"><\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #ccc;\">\u03b1 Acetophenone\/Phenol<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">1.8\u20132.2<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">1.8\u20132.2<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">1.8\u20132.2<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\"><\/td>\n<\/tr>\n<tr style=\"background-color: #f2f2f2;\">\n<td style=\"padding: 8px; border: 1px solid #ccc;\">\u03b1 Acetophenone\/Cinnamic acid<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">1.1\u20131.3<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">1.1\u20131.3<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">1.1\u20131.3<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\"><\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #ccc;\">\u03b1 1-Naphthol\/Phenol<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">3.9\u20134.4<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">3.9\u20134.4<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">3.9\u20134.4<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\"><\/td>\n<\/tr>\n<tr style=\"background-color: #f2f2f2;\">\n<td style=\"padding: 8px; border: 1px solid #ccc;\"><strong>Capacity<\/strong><\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc;\"><\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc;\"><\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc;\"><\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc;\"><\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #ccc;\">k&#8217; Toluene<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">17.0\u201322.0<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">19.0\u201324.0<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">17.0\u201322.0<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<h2>Applications of LiChroprep\u00ae Sorbent<\/h2>\n<ul>\n<li><strong>Peptide purification:<\/strong> LiChroprep\u00ae RP sorbents are used for fast, effective, and reproducible separation in peptide purification processes.<\/li>\n<li><strong>Biopharmaceutical and pharmaceutical API polishing:<\/strong> LiChroprep\u00ae Si products are well-suited for cost-effective, reliable polishing of biopharmaceutical and pharmaceutical APIs.<\/li>\n<li><strong>Preparative chromatography for purification of valuable compounds:<\/strong> Used in preparative chromatography for the purification of valuable compounds in research, pilot plant operation and production.<\/li>\n<\/ul>\n<h2>LiChroprep\u00ae Sorbent Product Portfolio<\/h2>\n<div class=\"res-table-wrapper\">\n<table style=\"width:100%; border-collapse: collapse; font-size: 14px;\">\n<thead>\n<tr style=\"background-color: #24326D;\">\n<th style=\"color: white; font-weight: bold; padding: 10px; border: 1px solid #ccc; text-align: left;\">Description<\/th>\n<th style=\"color: white; font-weight: bold; padding: 10px; border: 1px solid #ccc; text-align: center;\">Particle Size<\/th>\n<th style=\"color: white; font-weight: bold; padding: 10px; border: 1px solid #ccc; text-align: center;\">Qty<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #ccc;\">LiChroprep\u00ae RP-18<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">15\u201325 \u03bcm<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">0.1, 0.5, 10 kg<\/td>\n<\/tr>\n<tr style=\"background-color: #f2f2f2;\">\n<td style=\"padding: 8px; border: 1px solid #ccc;\">LiChroprep\u00ae RP-18<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">25\u201340 \u03bcm<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">0.1, 0.5, 5, 25 kg<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #ccc;\">LiChroprep\u00ae RP-18<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">40\u201363 \u03bcm<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">0.25, 1, 25 kg<\/td>\n<\/tr>\n<tr style=\"background-color: #f2f2f2;\">\n<td style=\"padding: 8px; border: 1px solid #ccc;\">LiChroprep\u00ae RP-8<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">40\u201363 \u03bcm<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">0.25, 1 kg<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #ccc;\">LiChroprep\u00ae Si 60<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">15\u201325 \u03bcm<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">1, 25 kg<\/td>\n<\/tr>\n<tr style=\"background-color: #f2f2f2;\">\n<td style=\"padding: 8px; border: 1px solid #ccc;\">LiChroprep\u00ae Si 60<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">25\u201340 \u03bcm<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">1 kg<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #ccc;\">LiChroprep\u00ae Si 60<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">40\u201363 \u03bcm<\/td>\n<td style=\"padding: 8px; border: 1px solid #ccc; text-align: center;\">0.25, 1, 25 kg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p>Trust Chemical Express, with over 23 years of expertise, as the official Merck distributor in Thailand. Access LiChroprep\u00ae Sorbent and related Merck products for preparative chromatography and purification applications. 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