Merck Amino Acid Reference Materials: Certified Standards for Accurate GC/MS and LC/MS Analysis
Precise amino acid analysis is vital for clinical diagnostics and research, particularly in metabolic disease detection and newborn screening. Merck’s certified amino acid reference materials meet rigorous industry demands by delivering reliable quantification and streamlined workflows for GC/MS and LC/MS methods. Use these standards to elevate your laboratory’s accuracy and consistency.
Benefits and Key Features of TraceCERT® Amino Acid Reference Materials
- Consistent, reliable quantitative results: Certified concentration values support dependable performance for quantitative applications in clinical and research environments.
- Broad analyte coverage: Wide selection of analytical standards and certified reference materials for amino acids, including native compounds and stable isotope-labeled internal standards.
- Flexible solution configurations: Available as single solutions and as multi-analyte or multi-component solution mixes.
- Stable, ready-to-use format: Products are supplied in a stable quantitative solution format that simplifies day-to-day laboratory workflows and helps minimize material waste.
- Traceable CRM classification: TraceCERT® amino acid reference materials are offered as certified reference materials with assigned concentration values for each component.
- Platform compatibility: Optimized or suitable for GC/MS, LC/MS, and LC-MS/MS platforms to support streamlined analytical workflows.
Key Features of Merck Amino Acid Reference Materials and CRMs
- Analyte Coverage: Wide selection of analytical standards and certified reference materials for amino acids.
- Internal Standard Formats: Product range includes native compounds and stable isotope-labeled internal standards.
- Solution Configurations: Available as single solutions and as multi-analyte or multi-component solution mixes.
- Certified Reference Material Class: TraceCERT® amino acid reference materials are offered as certified reference materials.
- Physical Format: Products are supplied in a stable, quantitative solution format.
- Concentration Assignment: Certified concentration values are provided for each component.
- Platform Compatibility: Amino acid reference materials are optimized or suitable for GC/MS and LC/MS platforms.
Applications and Usage of Amino Acid Reference Materials for GC/MS and LC/MS
- Preparation of internal standards for quantitative GC/MS, LC/MS, and LC-MS/MS applications.
- Preparation of controls, calibrators, and linearity standards for LC-MS/MS assays.
- System tuning and system suitability standards for GC/MS and LC/MS workflows, including quantitative amino acid analysis.
- Linearity verification and proficiency testing, including internal proficiency schemes.
- Diagnostic testing for amino acid analysis in inborn errors of metabolism and other metabolic diseases.
- Newborn screening programs and detection of metabolic diseases by GC/MS or LC/MS.
- Diagnosis of amino acid disorders and inborn errors of amino acid metabolism, including phenylketonuria, tyrosinemia, citrullinemia, non-ketotic hyperglycinemia, maple syrup urine disease, and homocystinuria.
Amino Acids Certified Reference Materials
| Description | Pack Size |
|---|---|
| Amino Acids Mix Solution certified reference material, TraceCERT® | 17 AAs at 2500 nmol/mL in 0.1M HCl |
| Stable Isotope Labeled Amino Acid Mix Solution 1 certified reference material, TraceCERT® | 17 SIL AAs at 1250-2500 nmol/mL in 0.1M HCl |
| Stable Isotope Labeled Amino Acid Mix Solution 2 certified reference material, TraceCERT® | 11 SIL AAs at 500-2500 nmol/mL in 0.1M HCl |
| Stable Isotope Labeled Amino Acid Mix 3 2500 nmol certified reference material, TraceCERT® | available soon |
| L-Alanine certified reference material, TraceCERT® | 100 mg |
| γ-Aminobutyric acid certified reference material, TraceCERT® | 50 mg |
| L-Arginine monohydrochloride certified reference material, TraceCERT® | 100 mg |
| L-Asparagine, certified reference material, TraceCERT® | 100 mg |
| L-Aspartic acid certified reference material, TraceCERT® | 100 mg |
| L-Cysteine certified reference material, TraceCERT® | 100 mg |
| L-Cystine certified reference material, TraceCERT® | 100 mg |
| 3,4-Dihydroxy-L-phenylalanine certified reference material, TraceCERT® | 50 mg |
| L-Glutamic acid certified reference material, TraceCERT® | 100 mg |
| L-Glutamine certified reference material, TraceCERT® | 100 mg |
| L-Histidine certified reference material, TraceCERT® | 100 mg |
| L-Isoleucine certified reference material, TraceCERT® | 100 mg |
| L-Leucine certified reference material, TraceCERT® | 100 mg |
| L-Lysine monohydrochloride certified reference material, TraceCERT® | 100 mg |
| L-Methionine certified reference material, TraceCERT® | 100 mg |
| L-Methionine sulfoximine certified reference material, TraceCERT® | 100 mg |
| L-Phenylalanine certified reference material, TraceCERT® | 100 mg |
| L-Proline certified reference material, TraceCERT® | 100 mg |
| L-Serine certified reference material, TraceCERT® | 100 mg |
| L-Threonine certified reference material, TraceCERT® | 100 mg |
| L-Tryptophan certified reference material, TraceCERT® | 100 mg |
| L-Tyrosine certified reference material, TraceCERT® | 100 mg |
| L-Valine certified reference material, TraceCERT® | 100 mg |
Amino Acids Analytical Standards
| Description | Pack Size |
|---|---|
| Amino Acid Standard | 17 AAs at 1.25-2.5 µmoles per mL in 0.1 N HCl |
| Amino acid standards for protein hydrolysates | 18 AAs at 0.25-0.5 µmole/mL in 0.2N sodium citrate, pH 2.2 |
| Amino acid standards for protein hydrolysates containing norleucine | Amino acids at 0.25-0.5 µmole/ml in 0.2N sodium citrate, pH 2.2 |
| Amino acid standards, physiological analytical standard, acidics, neutrals, and basics | 38 component mix |
| Amino acid standards, physiological analytical standard, acidics and neutrals | Amino acids at 1.25-2.5 µmole/ml |
| Amino acid standards, physiological analytical standard, basics | Amino acids and related compounds at 2.5 µmole/mL |
| β-Alanine | 100 mg |
| L-Alanine hydrochloride solution | 100 mM amino acid in 0.1M HCl |
| L-Arginine hydrochloride solution | 100 mM amino acid in 0.1M HCl |
| L-Cystine hydrochloride solution | 10 mM amino acid in 0.1M HCl |
| Glycine hydrochloride solution | 100 mM amino acid in 0.1M HCl |
| L-Histidine hydrochloride solution | 100 mM amino acid in 0.1M HCl |
| DL-Homocysteine | 25 mg |
| L-Isoleucine hydrochloride solution | 100 mM amino acid in 0.1M HCl |
| L-Leucine hydrochloride solution | 100 mM amino acid in 0.1M HCl |
| L-Lysine | 100 mg |
| L-Lysine hydrochloride solution | 100 mM amino acid in 0.1M HCl |
| L-Methionine hydrochloride solution | 100 mM amino acid in 0.1M HCl |
| DL-Norvaline | 100 mg |
| L-Phenylalanine | 25 g |
| L-Phenylalanine hydrochloride solution | 100 mM amino acid in 0.1M HCl |
| L-Proline hydrochloride solution | 100 mM amino acid in 0.1M HCl |
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